Chapters Transcript PuraPly AM & XT MOA Video PuraPly AM & XT Mechanism of Action Wound healing is a complex process requiring several key conditions. Among these are a healthy extracellular matrix ECM to provide a scaffold for proteins and cell migration and proliferation. A proper balance of matrix metalloprotein aces M MP S to help remove debris from the healing site and a clean and proper wound bed. During the healing process, bacteria can infiltrate the wound bed as bacteria multiply colonize and become cessile. They secrete an extracellular polymeric substance composed of polysaccharides, creating a protective barrier against antimicrobial agents. The combination of bacteria and the protective substance is known as biofilm because of the protection by the biofilm. An intense host immune response is generated in an ongoing attempt to eliminate the bacteria. As the host immune response intensifies of inflammatory cytokines and mms accumulate in the these the cm and other essential hants lead to inflammation and promote deliverable for further bacteria. As a result stalls leading to a chronic shar busy to physically remove biofilm. Studies show that biofilm can redevelop with four and be fully mature within. Therefore, sharp alone does not control microbial or prevent biofilm. Sharp debri is optimum combined with the native extracellular matrix scaffold antimicrobial to support wound healing A and XT provide a ation cross linked extra matrix scaffold for cellular migration and, and broad. So hexamethy by PHMB actively to provide antimicrobial effectiveness within the product to support pur A T have several unique features. First, the CM scaffold is arranged in layers to maximize surface areas for PM B saturation. Second, the cross link native ECM scaffold strengthens the matrix bonds to enhance resistance to degradation by M MP S. This helps reduce the hyper proo environment that stalls wound healing and supports persistence. Finally, PMB is a positively charged antimicrobial agent that specifically targets and destroys bacterial cells while remaining highly compatible with host tissue and sparing cells important for wound healing. Purify AM and purify XT contain a unique combination that provides a native extracellular matrix scaffold and sustained antimicrobial effectiveness within the product to support wound healing and aid in granulation tissue formation. Published October 22, 2024 Created by
